A scientific home for the Lymphex research program.

This paper proposes the Helical Limb Model, a systems-level hypothesis that repetitive rotational loading in paired-bone limb segments can alter fascial tension, interstitial pressure dynamics, and distal lymphatic transport. Rather than displacing established neuropathy etiologies, it frames impaired drainage and pressure-sensitive tissue mechanics as a potential cofactor in selected idiopathic or multifactorial neuropathic presentations.

This paper argues that age-related vascular stiffening may impair the pulsatile mechanical forces that support periarterial cerebrospinal fluid exchange, glymphatic clearance, and downstream meningeal lymphatic drainage. Within this framework, amyloid accumulation is treated not solely as an initiating lesion, but as a downstream manifestation and amplifier of broader clearance failure in the aging brain.

This white paper proposes that impaired craniofacial lymphatic drainage is a permissive condition for chronic rhinosinusitis, recurrent otitis media, allergic ENT disease, and related pediatric congestion syndromes. It reframes persistent inflammation as a failure of clearance across the nasal, sinus, nasopharyngeal, and middle-ear drainage axis, while also examining how dental and pediatric ENT interventions may compound existing drainage burden.

This white paper advances the hypothesis that age- and lifestyle-associated lymphatic stagnation within the pelvic basin is an upstream contributor to erectile dysfunction, prostatitis-like syndromes, and lower urinary tract symptoms. It presents a cranio-caudal congestion model in which declining lymphatic contractility, interstitial stagnation, vascular dysfunction, and tissue remodeling reinforce one another across the male pelvic floor.

This updated white paper argues that carpal tunnel syndrome may be driven not only by mechanical compression of the median nerve, but also by lymphatic stagnation at the distal radial and ulnar collecting junction of the wrist. Within this model, elevated compartmental pressure, intraneural edema, nocturnal worsening, and part of the benefit seen after carpal tunnel release can all be interpreted through impaired lymphatic egress and its downstream neurovascular consequences.